Grants

Active

R01 HD073352 (Hale) 2013-2018
NICHHD, NIH

“Biopsychosocial determinants of sleep and wellbeing for teens in Fragile Families”
The proposed research will investigate the biopsychosocial determinants of adolescent sleep, and the extent to which differential sleep patterns and behaviors during childhood contribute to differences in obesity and depression/depressive symptoms using the Fragile Families Study (FFS). The FFS is a national birth cohort study of health and development of children, with data collected at birth and ages 1, 3, 5, and 9, and, with recent NIH funding to locate and interview youths and mothers when the adolescents are age 15 (n~3,600). As an ancillary study to the parent FFS age 15 survey, this proposal aims specifically to study adolescent sleep.
Role: Subcontract Principal Investigator

1R01DK103663 - 01A1 (Wagner) 2015-2020
NIH/NIMH

“Lifestyle & medication management to lower diabetes risk in severe mental illness”

Goal: Serious mental illness (SMI), including chronic depression and post-traumatic stress disorder, are known risk factors for type 2 diabetes. The overarching goal of this study is to test the relative effects of lifestyle, medication management, and collaborative care interventions on diabetes risk in persons with SMI and significant health disparities. Physical activity and sleep will be measured by actigraphy.

Role: Subcontract Principal Investigator

Award No.1622766 (Gartenberg) 2016-2017

NSF/STTR

“The use of wrist-worn devices and auditory stimulation for evaluating sleep”

Goal: The goal of this study is to validate in young adults a new algorithm for detecting sleep stages using actigraphy, heart rate, and acoustic stimulation compared against polysomnography (gold standard).

Role: Subcontract Principal Investigator

UH2-AG052167 (Almeida & Smyth) 2015-2018

NIH/NIA

“Everyday Stress Response Targets in the Science of Behavior Change”

Goal: The overarching goal of this project is to utilize an experimental medicine approach to develop an efficient, ecologically valid, within-person approach to measuring and intervening on the deleterious effects of everyday stress on meeting recommended levels of two health behaviors: physical activity and sleep patterns.

Role: Co-Investigator

1R01HD087266 (Teti) 2016-2021

NIH/NICHD

“Parenting, Children's Sleep, and School Adjustment Across the Kindergarten Year”

Goal: This study will use an innovative measurement-burst design to assess child sleep (quality, duration, and lability), parenting, and co-parenting and personal distress as predictors of child sleep characteristics, with assessments obtained before kindergarten begins and three times across the school year. Children’s learning engagement, academic progress, socio-emotional functioning, executive functioning, and literacy skills will be assessed at all time points.

Role: Co-Investigator

1 T32 LM012415-01 (Ritchie) 2016-2021
Social Science Research Institute (SSRI), Pennsylvania State University

“Biomedical Big Data to Knowledge (B2D2K) Predoctoral Training Grant”

The Biomedical Big Data to Knowledge (B2D2K) Training Program at The Pennsylvania State University will bring together Data Science researchers and educators to create a truly transformative multi-disciplinary predoctoral training environment. The goal of the B2D2K program is to train a diverse cohort comprising the next-generation biomedical data scientists.

Role: Senior/Key Personnel

1UL1TR002014-01 (Sinoway) 2016-2020

Pennsylvania State University Hershey Medical Center
“Penn State Clinical and Translational Science Institute”

Advancing clinical and translational science to improve health and defeat disease requires a unique set of expertise and supports—ranging from capacity for effective multidisciplinary team science, to a cohesive infrastructure of research IT and data sharing, novel approaches to training a new and diverse workforce, and strengths in building partnerships with the varied communities we serve. We propose to build on the foundation we have established at Penn State, to further expand our capacity to motivate and support multidisciplinary translational research that reaches across our University and to other institutions, and educates a new generation of the workforce to achieve rigorous, high impact, clinical and translational science.

Role: Chair, Steering Committee, Clinical Research Committee

Pilot (Perfect) 2013-2018
“Students with Diabetes: Does Optimizing Sleep Promote Classroom, Behavioral, and Diesease-Related Improvement?”
Diabetes is one of the most common student health conditions that school personnel will encounter in their classroom, affecting 1 in 300 youth between the ages of 10 and 19 years. These youth represent a special group as this chronic health condition has been associated with both problems at school and difficulties with sleep.
Role: Subcontract Principal Investigator

P01 AG009975 (Czeisler) 2013-2018
NIH/NIA Program Project

Project 2: “Adverse metabolic impact of sleep loss in older adults: insulin resistance”
This Project will contribute to understanding the mechanisms by which sleep loss impairs metabolism in older adults, contributing to future research to reduce the risk of diabetes, improve existing therapies, and enhance the health and quality of life of older Americans whose sleep is insufficient.
Role: Project Leader

P01 AG009975-16A1 (Czeisler) 2013-2018
NIH/NIA Program Project

Project 1: “Recurrent circadian disruption & pancreatic β-cell responsiveness in older people”
This Project will contribute to understanding the distinct metabolic risks from circadian disruption, laying the groundwork for research designed to develop therapies targeted to reduce the risk of obesity, metabolic syndrome and diabetes, and enhance the health and quality of life of older Americans whose circadian rhythms are disrupted by age-related changes, irregular schedules, and/or night shift work.
Role: Co-Investigator

Completed

R01HL107240-01 (Buxton, PI) 2011-2016
NHLBI

“Evaluating cardiometabolic and sleep health benefits of a workplace intervention”
The Work, Family and Health Study is an ongoing, randomized, controlled trial of an innovative workplace intervention to improve employee health. This ancillary study adds objective health outcomes in mid level managers, a focus of the intervention, to evaluate the effects of the workplace intervention on managers' cardiometabolic and sleep health, and represents a unique opportunity to study the multi-level factors influencing health in the workplace.
Role: Principal Investigator

U01 AG027669 (Berkman, PI) 2008-2015
NIH

“Evaluating the Health Benefits of Workplace Policies and Practices - Phase II”
Although the prevalence of “family-friendly” policies in US workplaces has increased dramatically, few have been studied using scientifically sound designs. To address this, NIH and CDC formed the Work, Family, and Health Network (WFHN). During Phase 1, WFHN designed and conducted multiple pilot and feasibility studies. For Phase 2, the WFHN has been called upon to implement an innovative intervention based on Phase I pilot studies that is designed to increase family-supportive supervisor behaviors and employee control over work, and to evaluate the intervention using a group randomized experimental design.
Role: Subcontract Principal Investigator

Pilot (Noll, PI) 2016-2017
Social Science Research Institute (SSRI), Pennsylvania State University
“Female growth and development study 30-year follow up”
Prospective longitudinal studies of specific mechanisms by which sexual abuse impinges on development over the life course are needed. This substudy focuses on the relative impact of early maldevelopment on later adulthood (midlife) functioning, including sleep health and hair cortisol as a stress marker.
Role: Subcontract Principal Investigator

Big Data Pilot Grant (Chang, A-M, PI) 2015-2016
Penn State University Clinical & Translational Science Institute (CTSI) / funded by NIH
“Complex interactions of behavior, genes, and environment in the multi-system characterization of the effects of sleep loss on health, cardio-metabolic disease risk, cognition, and the epigenome”
This project examines effects of sleep restriction on glucose and lipid metabolism, adipocyte function, cognition, retinal blood flow, autonomic regulation of the heart, and physiologic measures of physiological stress, as well as transcriptome and epigenetic changes in blood mononuclear cells and adipocytes.
Role: Co-Investigator

Supplemental pilot (Olson, PI) 2013-2014
OHSU

“Sleep Actigraphy in a Trucker Weight Loss Intervention Trial”
The purpose of this subproject is to train researchers on the scoring of de-identified sleep actigraphy data to eventually determine the effects of a social support intervention in truckers. Long-haul truck drivers have overweight and obesity rates almost 20% higher than the general population. Obesity has established mortality and disease consequences, including heart disease, diabetes, and sleep apnea. Driver health is also a public safety hazard because obesity and sleep apnea increase the risk of deadly crashes. Despite the growing health crisis, there is a lack of effective weight loss and health promotion interventions for truck drivers. To address this research gap we developed an innovative intervention that is integrated with the job structure and modern technologies of truck driving.
Role: Subcontract Principal Investigator

R01 HL094806 (Scheer, PI) 2009-2014
NHLBI

“Mechanisms underlying adverse health consequences of shift work”
The goal of the present proposal is to determine the effect of simulated shift work on physiological changes that increase susceptibility to the development of diabetes, obesity, and cardiovascular disease and to determine whether this effect is amplified in individuals with pre-diabetes.
Role: Co-Investigator

Marino, PI 2011-2013
Robert Wood Johnson Foundation

"Quantifying Change in Cardiometabolic Disease Risk" has been approved for the amount of $10,000
The goal of this study is to integrate novel biostatistical and epidemiological methods with cardiometabolic expertise to develop and evaluate a cumulative cardiometabolic risk score that is optimized on modifiable risk factors so as to detect intervention or experimental effects.
Role: Co-Investigator

P01 AG009975 (Czeisler, PI) 2006-2013
NIH/NIA Program Project

“Sleep Aging and Circadian Rhythm Disorders”
Project 3 “Metabolic Aging: Endocrine And Cardiovascular Consequences Of Sleep Restriction (Buxton PI)
This project seeks to address that gap in our knowledge by using a well-established laboratory model to study what differences may exist between the sleep efficiency of older and younger subjects under conditions of chronic sleep restriction. Project #3 on ‘metabolic aging’ seeks to understand the endocrine and cardiovascular consequences of sleep restriction in both young and older subjects.
Role: Project Leader

R21 DK089378 (Scheer/Saxena, co-PIs) 2010-2012
NIDDK

“Impact of MTNR1B and CRY2 Variants on Sleep, Circadian Physiology and Metabolism”
The goal is to determine the impact of genetic variants of MTNR1B on circadian, metabolic and sleep variables and to help explain the increased risk for the development of diabetes in carriers of the risk SNP.
Role: Co-Investigator

ESRC-0977 (Buxton, PI) 2008-2011
Sepracor, Inc.

“Effects of daytime eszopiclone administration in shift workers on overnight wakefulness during a subsequent simulated nightshift”
The goal of this project is to determine whether improving daytime sleep quality in shiftworkers improves subsequent nighttime wakefulness and neurobehavioral performance.
Role: Principal Investigator

1U19 OH008861-01 (Sorensen, PI) 2009-2011
CDC

"Harvard Center of Excellence to Promote a Healthier Workforce": Project A - "Integrated approaches to improving the health and safety of health care workers”
The goal of this center is to establish a sustainable transdisciplinary program devoted to research, education and dissemination to facilitate the integration of occupational safety and health and health promotion.
The biomarker sub-study incorporates objective physiologic markers of health into the parent study.
Role: Subcontract Principal Investigator

UL1 RR025758 (Scheer, PI) 2009-2010
“Mechanistic impact of the novel MTNR1B Type 2 diabetes gene on changes in circadian metabolic and sleep physiology”
The goal is to determine the impact of genetic variants of MTNR1B on circadian, metabolic and sleep variables and to help explain the increased risk for the development of diabetes in carriers of the risk SNP.
Role: Co-Investigator

Grant (Berkman PI) 2007-2009
Alfred P. Sloan Foundation

Longitudinal Analyses Linking Workplace Flexibility to Physical Health Outcomes
The goal of this project is to determine longitudinal relationships between work factors and health outcomes.