Publications

Dr. David Vandenbergh publications

Boggs, N.T., H.D. Bruton, D.H. Craig, J.A. Helpern, H.C. March, M.D. Pegram, Vandenbergh, D.J., K.A. Koehler and R.G. Hiskey, (1982) Chemical Modification of Peptides Containing Gamma-Carboxyglutamic Acid, J. Org. Chem. 47:1812-1816.

Vandenbergh, D.J., Carol W. Wuenschell, Nozomu Mori, and David J. Anderson, (1989) Chromatin Structure as a Molecular Marker of Cell Lineage and Developmental Potential in Neural Crest-Derived Chromaffin Cells. Neuron 3:507-518.

Mori, N., S.J. Birren, R. Stein, D. Stemple, Vandenbergh, D.J., C.W. Wuenschell, and D.J. Anderson, (1990) Contributions of Cell-extrinsic and Cell-intrinsic Factors to the Differentiation of a Neural-crest-derived Neuroendocrine Progenitor Cell. Cold Spring Harbor Symposia on Quantitative Biology, 55:255- 264.

Vandenbergh, D.J., Magdalena James-Pederson, and Ross C. Hardison, (1991). An Apparent Pause Site in the Transcription Unit of the Rabbit Alpha-Globin Gene. J. Mol. Biol., 220:255-270.

Hardison, R., D. Krane, Vandenbergh, D.J., J.-F. Cheng, J. Mansberger, J. Taddie, S. Schwartz, X.Q. Huang, W. Miller, (1991) Sequence and Comparative Analysis of the Rabbit Alpha-like Globin Gene Cluster Reveals a Rapid Mode of Evolution in a G+C Rich Region of Mammalian Genomes. J. Mol. Biol., 222:233-249.

Vandenbergh, D.J., N. Mori and D.J. Anderson, (1991) Co-expression of Multiple Neurotransmitter Enzyme Genes in Normal and Immortalized Sympathoadrenal Progenitor Cells. Developmental Biology 148:10-22.

Mori, Nozomu, Christopher Schoenherr, Vandenbergh, D.J., and David J. Anderson (1992) A Common Silencer Element in the SCG10 and Type II Sodium Channel Genes Binds a Factor Present in Non-Neuronal Cells but Not in Neuronal Cells. Neuron 9:45-54.

Vandenbergh, D.J., Antonio M. Persico, and George R. Uhl, (1992) A Human Dopamine Transporter cDNA Predicts Reduced Glycosylation, Displays a Novel Repetitive Element and Provides Racially-Dimorphic Taq I RFLPs. Molecular Brain Research 15:161-166.

Vandenbergh, D.J., Antonio M. Persico, Anita L. Hawkins, Constance A. Griffin, Xiang Li, Ethylin Wang Jabs, and George R. Uhl, (1992) Human Dopamine Transporter Gene (DAT1) Maps to Chromosome 5p15.3 and Displays a VNTR. Genomics 14:1104-1106.

Persico, Antonio M., Vandenbergh, D.J., Stevens S. Smith, and George R. Uhl, (1993) Dopamine Transporter Gene Polymorphisms are not Associated with Polysubstance Abuse. Biological Psychiatry 34:265-267.

Mori, N., Y. Tajima, H. Sakaguchi, Vandenbergh, D.J., H. Nawa, and P.M. Salvatera (1993) Partial Cloning of the Rat Choline Acetyltransferase Gene and in situ Localization of its Transcripts in the Cell body of Cholinergic Neurons in the Brain Stem and Spinal Cord. Molecular Brain Research 17:101-111.

Lossie, Amy C., Vandenbergh, D.J., George R. Uhl, and Sally Camper, (1994) Localization of the Dopamine Transporter Gene (DAT1) on Mouse Chromosome 13. Mammalian Genome 5:117-118.

Vandenbergh, D.J., Donovan, David M.*, Michael Perry, Geoffrey S. Bird, George R. Uhl. (1995) Human and Mouse Dopamine Transporter Genes: Conservation of 5'-flanking Sequence Elements and Gene Structures. Mol. Brain Res. 30:327-335. *Co-first authors with Donovan listed first.

Gelernter, Joel, Vandenbergh, D.J., S.D. Kruger, D.L. Pauls, R. Kurlan, A.J. Pakstis, K.K. Kidd, and G. Uhl. (1995) The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette's Syndrome. Genomics 30:459-463.

Kaddis, F., E.D. Clarkson, M. Weber, Vandenbergh, D.J., D. Donovan, J. Mallet, P. Horellou, G.R. Uhl, and C.R. Freed. (1997) Intra-Striatal Grafting of Cos Cells Expressing Human Aromatic-L-Amino-Acid Decarboxylase: Neurochemical Effects. J. Neurochem. 68:1520-1526.

Vandenbergh, D.J., Lawrence A. Rodriguez, Ivan Miller, George R. Uhl and Herbert M. Lachman (1997) A HighActivity Catechol-O-Methyltransferase Allele is More Prevalent in Polysubstance Abusers. Am. J. Med. Genetics 74:439-442.

Vandenbergh, D.J., Alan Zonderman, Jocelyn Huang, George R. Uhl, and Paul R. Costa, Jr. (1997) No Association between Novelty Seeking and Dopamine D4 Receptor (DRD4) exon III Seven Repeat Alleles in Baltimore Longitudinal Study on Aging Participants. Molecular Psychiatry 2:417-419.

Wang, Xaio-Bing, Masahiko Funada, Yasuo Imai, Randall S. Revay, Hiroshi Ujike, Vandenbergh, D.J., George R. Uhl. (1997) rGBeta1: A Psychostimulant-Regulated Gene essential for Establishing Cocaine Sensitization. J. Neurosci. 17: 5993-6000.

Rothman, Richard B., Mayme L. Silverthorn, John R. Glowa, Dorota Matecka, Kenner C. Rice, F. Ivy Carroll, John S. Partilla, George R. Uhl, Vandenbergh, D.J., and Christina M. Dersch (1998) Studies of the Biogenic Amine Transporters. VII. Characterization of a Novel Cocaine Binding Site Identified with [125I]RTI-55 in Membranes Prepared from Human, Monkey and Guinea Pig Caudate. Synapse 28: 322-338.

Mitsuhata, Chieko, Shigeo Kitayama, Katsuya Morita, Vandenbergh, D.J., George R. Uhl, and Toshihiro Dohi (1998) Tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine. Molecular Brain Research 56: 84-88.

Vandenbergh, D.J., Miles D. Thompson, Ed H. Cook, Elisabeth Bendahhou, Tuan Nguyen, Matthew D. Krasowski, Dorsa Zarrabian, David Comings, Edward M. Sellers, Rachael F. Tyndale, Susan R. George, Brian F. O’Dowd, and George R. Uhl (2000) Human Dopamine Transporter Gene: Coding Region Conservation Among Normal, Tourette’s Disorder, Alcohol Dependent, and Attention Deficit Hyperactivity Disorder Populations. Molecular Psychiatry 5:283-292.

Vandenbergh, D.J., Lawrence A. Rodriguez, Elisabeth Hivert, Jocelyn Huang Schiller, Gregory Villareal, Elizabeth W. Pugh, Herb Lachman, and George R. Uhl (2000) Long Forms of the Dopamine Receptor (DRD4) Gene VNTR are More Prevalent in Substance Abusers: No Interaction with Functional Alleles of the Catechol-O-Methyltransferase (COMT) Gene. Am. J. Med. Genet., Neuropsychiatric Genetics Section 96: 678-683.

McClearn, Gerald E. and Vandenbergh, D.J. (2000) The Structure and Limits of Animal Models: Examples from Alcohol Research. Institute for Laboratory Animal Research Journal 41:144-152.

Barr, Cathy L., Chun Xu, Jaimie Kroft, Yu Feng, Karen Wigg, Gwyneth Zai, Rosemary Tannock, Russell Schachar, Molly Malone, Wendy Roberts, Marcus M. Nothen, Frank Gruenhage, Vandenbergh, D.J., George Uhl, Glen Sunohara, Nicole King, and James L. Kennedy (2001) Haplotype Study of Four Polymorphisms at the Dopamine Transporter Locus Confirm Linkage to Attention-Deficit Hyperactivity Disorder. Biological Psychiatry 49: 333339.

Vandenbergh, D.J., Christina J. Bennett, Michael D. Grant, Andrew A. Strasser, Richard O'Connor, George P. Vogler and Lynn T. Kozlowski (2002) Smoking Status and the Human Dopamine Transporter Variable Number of Tandem Repeats (VNTR) Polymorphism: Failure to Replicate and Finding that Never-smokers May be Different. Nicotine and Tobacco Research 4:333-340.

Kozlowski, Lynn T., George P. Vogler, Vandenbergh, D.J., Andrew A. Strasser, Richard J. O’Connor, Berwood A. Yost (2002) Using a Telephone Survey to Acquire Genetic and Behavioral Data Related to Cigarette Smoking in “Made Anonymous” and “Registry” Samples. American Journal of Epidemiology 156:68-77.

Vandenbergh, D.J., Christina J. Bennett, Michael D. Grant, Andrew A. Strasser, Richard O'Connor, George P. Vogler and Lynn T. Kozlowski (2002) DAT’s not all, but it may be more than we realize. Response to: “Nonreplication of Genetic Association Studies: Is DAT All Folks?” by G. Swan and C. Lerman. Nicotine and Tobacco Research 4:251-252.

Vandenbergh, D.J., Ryan Peterson, Kathrine Heron, Karl B. Shpargel, Abigail Woodroffe, David A. Blizard, Gerald E. McClearn and George P. Vogler (2003) Simple Tests to Detect Errors in High-Throughput Genotype Data in the Molecular Laboratory. Journal of Biomolecular Techniques 14(1):9-16. PMC2279894

Klein, Laura C., Michele M. Stine, Donald W. Pfaff, and Vandenbergh, D.J. (2003) Maternal Nicotine Exposure Increases Nicotine Preference in Periadolescent Male but not Female C57BL/6J Mice. Nicotine & Tobacco Research 5:117-124.

Kerin, Tara K. George P. Vogler, David A. Blizard, Joseph T. Stout, Gerald E. McClearn and Vandenbergh, D.J.
(2003) Anogenital Distance Measured at Weaning is Correlated with Measures of Blood Chemistry and Behaviors in 450 Day-Old Female Mice. Physiology & Behavior 78:697-702.

Vandenbergh, D.J., Kate Anthony, and Keith Whitfield (2003) Optimizing DNA Yield from Buccal Swabs in the Elderly: Attempts to Promote Buccal Cell Growth in Culture. American Journal of Human Biology 15:637-642.

Kozlowski, Lynn T., George P. Vogler, David J. Vandenbergh, Andrew A. Strasser, Richard J. O’Connor (2003) Response to a Letter to the Editor - "Letter to the Editor: Using a Telephone Survey to Acquire Genetic and Behavioral Data Related to Cigarette Smoking in "Made-Anonymous" and "Registry" Samples." American Journal of Epidemiology 158:192.

Vandenbergh, D.J., Michael D. Grant, Virginia Severns (2003) A Simple Tandem Repeat Polymorphism is present Eighth Intron of FLJ12960, a Possible Queuine Salvage Enzyme Gene. Molecular and Cellular Probes 17(6):319-320.

Lionikas, A., D. Blizard, D.J. Vandenbergh, M. Glover, G. Vogler, G.E. McClearn, and L. Larsson (2003) Genetic Architecture of fast- and slow-twitch skeletal muscle weight in 200-day-old mice of the C57BL6/J and DBA/2J Lineage. American Journal of Physiology: Physiological Genomics 16:141-152.

Klein, Laura Cousino, Michele M. Stine, David J. Vandenbergh, Courtney A. Whetzel and Helen M. Kamens (2004) Sex Differences in Voluntary Oral Nicotine Consumption by Adolescent Mice: A Dose-Response Experiment. Pharmacology Biochemistry and Behavior 78:13-25.

Blizard, David A., David J. Vandenbergh, Akilah L. Jefferson, Cynthia D. Chatlos, George P. Vogler, Gerald E. McClearn. (2004) Effects of periadolescent ethanol exposure on alcohol preference in two BALB substrains. Alcohol 34(2-3):177-185.

Lang, Dena H., Neil A. Sharkey, Holly A. Mack, George P. Vogler, David J. Vandenbergh, David A. Blizard, Joseph T. Stout, Gerald E. McClearn (2005) Quantitative Trait Loci Analysis of Structural and Material Skeletal
Phenotypes in C57BL/6J and DBA/2 F2 and RI Mice. Journal of Bone and Mineral Research 20:88-99. PMC1201529

Lang, Dean H., Neil A. Sharkey, A. Lionikas, Holly A. Mack, Lars Larson, George P. Vogler, David J. Vandenbergh, David A. Blizard, Joseph T. Stout, Joseph P. Stitt, Gerald E. McClearn (2005) Adjusting Data to Body Size: A Comparison of Methods as Applied to Quantitative Trait Loci (QTL) Analysis of Musculoskeletal Phenotypes. Journal of Bone and Mineral Research) 20(5):748-757 PMC1201530

Lionikas, A., Blizard D.A., Gerhard G.S., Vandenbergh D.J., Stout J.T., Vogler G.P., McClearn G.E., and Larsson L. (2005) Genetic Determinants of Fast- and Slow-Twitch Skeletal Muscle Weight in 500-day Old Mice of the
C57BL/6J and DBA/2J Lineage. Physiological Genomics 21(2):184-192

O'Connor RJ, Kozlowski LT, Vandenbergh, D.J., Strasser AA, Grant MD, & Vogler GP (2005). An examination of early smoking experiences and smoking status in a national cross-sectional sample. Addiction 100:1352-1357.

Foreman, Jennifer E, David A. Blizard, Glenn Gerhard, Holly A. Mack, Dean H. Lang, Kathryn L. Van Nimwegen, George P. Vogler, Joseph T. Stout, Zakariya K. Shihabi, James W. Griffith, Joan M. Lakoski, Gerald E. McClearn, and David J. Vandenbergh (2005) Serum Alkaline Phosphatase Activity is Regulated by a Chromosomal Region Containing the Alkaline Phosphatase 2 (Akp2) Gene in C57BL/6J and DBA/2J Mice. Physiological Genomics 23(3):295-303.

Lionikas, A., Blizard D.A., Vandenbergh D.J., Stout J.T., Vogler G.P., McClearn G.E., and Larsson L. (2006) Genetic Determinants of Weight of Fast- and Slow-Twitch Skeletal Muscles in Old Mice. Mammalian Genome 17:615628.

Johannes F, Blizard DA, Lionikas A, Lang DH, Vandenbergh, D.J., Stout JT, Strauss JA, McClearn GE, and Vogler GP (2006) QTL Influencing Baseline Hematocrit in the C57BL/6J and DBA/2J Lineage: Age-Related Effects. Mammalian Genome 17:689-699.

Dar DE, Metzger TG, Vandenbergh, D.J., and Uhl GR (2006) Dopamine uptake and Cocaine binding mechanisms: The involvement of charged amino acids from the transmembrane domains of the human dopamine transporter. European Journal of Pharmacology 538(1-3):43-7.

Bower, Abbey L., Dean H. Lang; George P. Vogler, David J. Vandenbergh, David A. Blizard, Joseph T. Stout, Gerald E. McClearn, and Neil A. Sharkey (2006) QTL Analysis of Trabecular Bone in BXD F2 and RI Mice. Journal of Bone and Mineral Research 21(8):1267-75.

Rippel CA, Kobets AJ, Yoon DY, Williams PN, Shugart YY, Bridges DD, Vandenbergh, D.J., Singer HS. (2006) Norepinephrine Transporter Polymorphisms in Tourette Syndrome With and Without ADHD: No Evidence for Significant Association. Psychiatric Genetics 16(5):179-180.

Yoon, Dustin Y., Christopher A. Rippel, Andrew J. Kobets, Christina M. Morris, Jennifer E. Lee, Phillip N. Williams, Dana D. Bridges, David J. Vandenbergh, Yin Y. Shugart, Harvey S. Singer (2007) Dopaminergic Polymorphisms in Tourette Syndrome: Association with the DAT Gene (SLC6A3) American Journal of Medical Genetics B 144(5):605-610.

Petrill SA, Deater-Deckard K, Thompson LA, Schatschneider C, Dethorne LS, Vandenbergh, D.J.. (2007) Longitudinal genetic analysis of early reading: The Western Reserve Reading Project. Read Writ. 20(1-2):127-146. PMID: 19829751; PMC2760987

Whitfield, K.E., King, G., Moller, S., Edwards C., Nelson, T., & Vandenbergh D. (2007) Concordance Rates for Smoking Among African American Twins. Journal of the National Medical Association 99(3):213-217.

Vandenbergh, D.J., Richard J. O’Connor, Michael D. Grant, Akilah L. Jefferson, George P. Vogler, Andrew A. Strasser, and Lynn T. Kozlowski (2007) Dopamine Receptor Genes (DRD2, DRD3, and DRD4) and Gene-Gene Interactions Associated with Smoking-Related Behaviors. Addiction Biology 12(1):106-116.

Han B, Altman NS, Mong JA, Klein LC, Pfaff DW, and Vandenbergh, D.J. (2008) Comparing quantitative trait loci and gene expression data for sequenced organisms. Advances in Bioinformatics 2008:Article ID 719818, 6 pages. PMC2775685

DeThorne, Laura Segebart, Stephen A. Petrill, Ron Channell, Sara Hart, Rebecca Campbell, Kirby Deater-Deckard, Lee Anne Thompson, Chris Schatschneider, David J. Vandenbergh (2008) Genetic Effects on Children’s Conversational Language Use. Journal of Speech, Language, & Hearing Research 51(2):423-35. PMC2435205

Blizard DA, Vandenbergh, D.J., Lionikas A, and McClearn GE, (2008) Learning in the two-bottle alcohol preference test. Alcohol: Clinical and Experimental Research 32(12): 2041-6.

Blizard DA, Lionikas A, Vandenbergh, D.J., Vasilopoulos T, Gerhard GS, Griffith JW, Klein LC, Stout JT, Mack H, Lakoski JM, Larsson L, Spicer JM, Vogler GP, McClearn GE. (2009) Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiological Genomics 36(3):158-66. PMCID: PMC2646459

Whitfield KE, Yao X, Vogler GP, Hayward M, Vandenbergh, D.J. (2009) A Genetic Analysis of Hypertension in African American Adults. Ethnicity and Disease 19(1):18-22.

Lang, Dena H., Conroy DE, Lionikas A, Mack HA, Larsson L, Vogler GP, Vandenbergh, D.J., Blizard DA, McClearn GE, Sharkey NA. (2009) Bone, Muscle and Physical Activity: Structural Equation Modeling of Relationships and Genetic Influence with Age. Journal of Bone and Mineral Research 24:1608-1617. PMC2730930

Foreman JE, Lionikas A, Lang DH, Gyekis JP, Krishnan M, Sharkey NA, Gerhard GS, Grant MD, Vogler GP, Mack HA, Stout JT, Griffith JW, Lakoski JM, Hofer SM, McClearn GE, Vandenbergh, D.J., and Blizard DA (2009) Genetic Architecture for Hole-board Behaviors Across Substantial Time Intervals in Young, Middle-aged, and Old Mice. Genes, Brain and Behavior 8: 714-27.

Gyekis JP, Foreman JE, Anthony K, Klein LC, and Vandenbergh, D.J.. (2010) Activity-related behaviors in the holeboard predict nicotine consumption in C57B6 mice prenatally exposed to nicotine. Behavioral Brain Research 206:139-142.

Gyekis JP, Foreman JE, Anthony K, Klein LC and Vandenbergh, D.J., (2009) Perinatal Nicotine Exposure Delays Genital Development in Mice. Reproductive Toxicology 29(3):378-380.

Lang DH, Gerhard GS, Griffith JW, Vogler GP, Vandenbergh, D.J., Blizard DA, Stout JT, Lakoski JM, and McClearn GE. (2010) Quantitative Trait Loci (QTL) Analysis of Longevity in C57BL/6J byDBA/2J (BXD) Recombinant Inbred Mice. Aging Clinical and Experimental Research 22(1):8-19.

Sloane LB, Stout JT, Vandenbergh, D.J., Vogler GP, Gerhard GS, and McClearn GE (2010) QTL Analysis of Tail Tendon Break Time in Mice of C57BL/6J and DBA/2J Lineage. J. Gerontology (Biological Sci)

Gyekis J*, Blizard DA, Stout JT, Vandenbergh DJ, McClearn GE, Hager R. (2011) Genetic and Maternal Effects on Offspring Mortality in Mice. Evolutionary Biology 38(4):434-440

Kapelewski CH, Vandenbergh DJ, Klein LC (2011) Effect of Monoamine Oxidase Inhibition on Rewarding Effects of Nicotine in Rodents. Current Drug Abuse Reviews 4:110-120.

Gyekis JP*, Dingman MA*, Revitsky AR, Bryant BP, Vandenbergh DJ, Frank ME, Blizard DA. (2012) Gustatory, trigeminal, and olfactory aspects of nicotine intake in three mouse strains, Behav Genet. Sep;42(5):820-9 PMID: 22618163

Lionikas A, Meharg C, Derry JMJ, Ratkevicius A, Carroll AM, Vandenbergh DJ, Blizard DA, (2012) Resolving Candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses. BMC Genomics Nov 5;13:592. doi: 10.1186/1471-2164-13-592.

Dingman MA*, Gyekis JP*, Whetzel CA, Klein LC, Vandenbergh DJ** (2013) Age-Specific Locomotor Responses to Nicotine in Yellow and Mottled Avy/a Mice. BioMed Central Research Notes, 6(1):497. doi: 10.1186/10.1186/1756-0500-6-497, URL: http://www.biomedcentral.com/1756-0500/6/497) PMID 24289264

Vandenbergh DJ**, Schlomer GL* (2014) Applying Genomic Function to Genetic Studies of Nicotine Addiction: Pharmacogenomics and the ENCODE Project. Physiology, Biochemistry & Behavior, (Jan 31, 2014) (http://dx.doi.org/10.1016/j.pbb.2014.01.009)

Weinhouse C, Anderson OS, Bergin IL, Vandenbergh DJ, Gyekis JP*, Dingman MA*, Yang J, Dolinoy DC (2014) Perinatal Bisphenol A Exposure Promotes Dose-Dependent Incidence of Murine Hepatic Tumors. Environmental Health Perspectives) 122(5):485-91. doi: 10.1289/ehp.1307449. Epub 2014 Jan 17. PMID: 24487385

Heiderstadt KM, Vandenbergh DJ, Gyekis JP*, Blizard DA. Communal nesting increases pup growth but has limited effects on adult behavior and neurophysiology in inbred mice. J Am Assoc Lab Anim Sci. 2014;53(2):152-60. PubMed PMID: 24602541; PubMed Central PMCID: PMC3966271.

McClearn GE, Vandenbergh DJ, Stout JT, and McCarter RJ (2014) Exploiting Causal Complexity in Aging. Annual Review of Gerontology and Geriatrics, 34(1): 229-241 ed. R. Sprott, Springer, New York

Cleveland HH, Schlomer GS*, Vandenbergh DJ, Feinberg M, Greenberg M, Spoth R, Shriver MD, Zaidi AA, Hair KL* (2014) Influences of Interventions, Parenting, and the DRD4 Gene on Alcohol Use in Early Adolescence, Developmental Psychopathology (In press as of April 28).